药理 内脏系统(国外英文资料).docVIP

药理 内脏系统(国外英文资料) Internal system Antihypertensive drugs hypertension 1 definition Classification and diagnostic criteria 1) cause: primary hypertension, secondary hypertension; 2) progression of the disease progression: delayed hypertension; Acute hypertension; 3) the degree of diastolic blood pressure and the degree of damage to the target organ: Light (1), moderate (2), heavy (3); General diastolic pressure is greater than 12.0 kPa or systolic pressure is greater than 18.7 kPa for hypertension. Neuromodulation: the sympathetic nervous system Classification of antihypertensive drugs 1. The diuretic Sympathetic nerve suppressor Renin-angiotensin inhibition system 4. Calcium antagonist medicine vasodilator A: diuretic medicine Type of diuretic commonly used in antihypertensive: The active part of thiazide is the distal convoluted tubule. The principle of anti-hypertension: Early: discharge water, electrolyte Poststage: the decline of the extracellular Na + ion leads to the reduction of Ca2 + in the smooth muscle cells and the decrease in the ability of the vasculature to contract. Calcium channel blockers Common drugs: more, including nitropine and neanderthals Blood pressure principle: block the calcium channel, reduce the concentration of Ca2 + in the smooth muscle cells of the blood vessel, and relax the blood vessels. (4) b receptor blocker Propranolol adrenaline-blocking [decompression] Oral contraction is slow and depressurization is mild; No postural hypotension; Long-term use is not easy to produce tolerance The principle of the reduction of a receptor blocker: Reduce your heart output Inhibiting the release of renin Multiple sites inhibit the activity of sympathetic nervous system Increase the synthesis of the leading cyclin 【 application 】 Single use for mild hypertension (antihypertensive first-line medications). With diuretic drugs, the vasodilator is used for middle and high blood pressure, with angina and cardiac arrhythmia, and the effect of high nephro