SSR评估补阳还五汤加减治疗糖尿病自主神经病变.doc

交感皮肤反应评估补阳还五汤加减治疗糖尿病自主神经病变 王厹东 赵虹 [摘要] 目的 运用交感皮肤反应(SSR)研究补阳还五汤加减治疗糖尿病自主神经病变(DAN)的临床疗效。 方法 47例糖尿病患者和30例健康者分别进行SSR测定。将其中检得检得36例糖尿病自主神经病变患者按交感皮肤反应可引出波形者28例随机分为两组,治疗组15例予补阳还五汤加减汤剂和甲钴胺口服,对照组13例以相同剂量甲钴胺治疗。结果 糖尿病患者自主神经功能检测中交感皮肤反应异常率为63%,SSR波潜伏期明显延长或缺失,波幅降低。治疗组和治疗对照组与健康对照组潜伏期测定相比差异有显著意义(P＜0.01)。补阳还五汤加减可不同程度地减轻病人的肢体麻木、疼痛及发凉等临床症状,减轻DAN之发作性晕厥、眩晕、心悸、多汗等临床症状,SSR波潜伏期也有明显改善,治疗前后相比差异有显著意义(P＜0.001),与甲钴胺治疗组对比差异有显著意义(P＜0.001)。治疗过程中均未发现明显不良反应。结论 补阳还五汤加减治疗糖尿病自主神经病变有效,SSR可作为评估临床疗效的参考指标。 [关键词] 糖尿病自主神经病变;补阳还五汤;交感皮肤反应 Evaluation of sympathetic skin response on the treatment of diabetic autonomic neuropathy with Modified “Buyang Huanwu”Decoction WANG Qiudong*,ZHAO Hong. Department of Neurology and Neuroelectrophysiological Research of Traditional Chinese and Western Medicine,*PuDong New Area Hospital of TCM,ShangHai 201200,China.YueYang Hospital of Integrated Traditional and Western Medicine(ZHAO Hong) Corresponding Author:Wang Qiudong,Zip code 201200,Pudong New Area of Shanghai Chinese Medicine Hospital Department of Neurology.Email: drwangqiudong@ [Key words] Sympathetic skin response; Diabetic autonomic neuropathy;“Buyang Huanwu” Decoction ABSTRACT: Objective ?To evaluate the efficacy of Modified “Buyang Huanwu”Decoction in the treatment on15 patients with diabetic autonomic neuropathy diagnostic value of autonomic nerve function tests for detecting the early diabetic autonomic dysfunction. Methods Sympathetic skin response test were performed?in 47 typeⅡdiabetic patients,and their results were compared and analyzed with those of 30 healthy volunteers.Absence of the responses was found in 8 patients remarkably decreased in amplitude.The abnormal ratio was 63%.Conducting pre- and post-clinical evaluations on 15/13 patients with diabetic autonomic neuropathy and measuring their latency and amplitude.Electric stimulation was applied to median nerve and response was recorded simultaneously at contralateral palm. Results? There was significant difference between diabetic patients and hea