自身免疫病英文要领.pptVIP

Rheumatoid arthritis Etiology and Pathogenesis initiated by activation of T-helper cells which produce cytokines and activate B cells to produce antibodies HLA-DR4/DR1 associated with increased incidence 80% of patients with rhematoid factors (antibodies against Fc portion of IgG) precise trigger which initates destructive immune response is not known Rhematoid arthritis Clinical course symmetrical, polyarticular arthritis weakness, fever, malaise may accompany joint symptoms stiffness of joints in AM early, then progresses to claw-like deformities anemia of chronic disease present in