己酮可可碱在心脏衰竭的Meta分析的临床试验.pdf

ORIGINAL RESEARCH ARTICLE Pentoxifylline in Heart Failure: A Meta-Analysis of Clinical Trials 1 € 2 3 4 5 Sebastien Champion, Nathanael Lapidus, Godefroy Cherie, Vincent Spagnoli, Juliette Oliary Alain Cohen Solal4 ^ 1 Reanimation Medicale et Toxicologique, Hopital Lariboisiere, Paris, France ^ 2 Biostatistiques, Hopital Saint Antoine, Paris, France 3 Pharmacie des batignoles, Paris, France ^ 4 Cardiologie, Hopital Lariboisiere, Paris, France ^ 5 Pharmacie, Hopital Lariboisiere, Paris, France Keywords ABSTRACT heart failure; inflammation; meta-analysis; Background: Pentoxifylline possess antiinflammatory and rheological properties and has pentoxifylline; tumor necrosis factor. been tested in heart failure (HF). Methods: A comprehensive search was performed from Correspondence 1980 until July 2013 in PubMed, to identify randomized controlled trials evaluating pentox- ifylline versus placebo in HF, to determine impact on mortality. Search strategy is as follows: Sebastien Champion, Reanimation Medicale et ^ “Pentoxifylline” AND “heart” AND “trial”. Study selection of six randomized controlled Toxicologique, Hopital Lariboisiere, 2 rue A. trials evaluating mortality as outcome. Then, we conducted a meta-analysis of randomized Pare, 75010 Paris, France. Tel.: 00331 49 95 84 42;