放疗联合靶向药物治疗食管癌的研究进展.pdf

安 徽 医 药 Anhui Medical and Pharmaceutical Journal 2016 Jul,20(7) • 1225 • ◊ 综 述 ◊ 放疗联合靶向药物治疗食管癌的研究进展 殷英，杨林 (安徽医科大学第一附属医院放疗科，安 徽 合 肥 230022) 摘要 :在我国，食道癌是癌症死亡的第四大最常见的原因,严重威胁人类的健康。手术是食管癌治疗的重要方式，但对于不可 手术的进展期食管癌患者，放化疗是其标准的治疗方式。然而目前的治疗方式预后仍然欠佳。因此，有必要开发更有效的新 药融人该综合治疗模式中。靶向药物联合放疗在头颈部肿瘤治疗中已被证实能使患者获益。本综述集中阐述了在食管癌治 疗中靶向药物的安全性及有效性，同时指出靶向药物与放射治疗相结合显示了良好的耐受性及令人满意的近期疗效，值得更 深人的临床试验进一步研究。 关键词 :食管肿瘤;化放疗;分子靶向治疗 doi ： 10. 3969/j . issn . 1009 - 6469. 2016.07.001 Research progress of radiotlierapy combined targeted drug in treatment of esophageal cancer YINYing’ YANGLin {Department of Radiotherapy yFirst AAiUcited Hospital of Anhui Medial University ,Hefei, Anhui 230022，China ) Abstract:In China， esophagea cancer is the fourth most common cause of cancer death， which has a serious threat to human health . Surgery is the cornerstone in treatment for esophagea cancer,and chemoradiotherapy is the standard treatment for patients with loca y advanced esophagea squamous ce carcinoma who are unsuitable for surgery - However,prognosis for these patients remains poor . Thus ， there is a necessity to integrate more effective nove drugs into the multimoda treatment . A benefit of targeted therapy has been shown in head and neck cancer in combination with radiotherapy . This review focuses on the safety of esophagea cancer,and points out that targeted drug combined with radiation therapy displays a good tolerance -term effect . Further clinica tria of targeted drug plus radiation for patients with esophagea Key words ： Esophagea Neoplasms ；Chemoradiotherapy ； Molecular Targeted Therapy 食管癌是全球常见的恶性肿瘤之一，尤其高发 分子靶向药物治疗是利用肿瘤发生、发展、侵 于包括中国在内的东亚地区。在我国，食管癌发病 袭、扩散、转移等过程中起关键作用的蛋白分子作 率和死亡率分别占