英国新生儿碘暴露对甲功的影响.pdf

J. Perinat. Med. 2016; aop Fiona L.R. Williams*, Jennifer Watson, Chris Day, Aung Soe, Sateesh K. Somisetty, a Lesley Jackson, Elena Velten and Anita Boelen Thyroid dysfunction in preterm neonates exposed to iodine DOI 10.1515/jpm-2016-0141 to topical iodine prior to caesarean section compared to Received April 20, 2016. Accepted July 22, 2016. unexposed infants, a relationship which persisted after Abstract adjustment. Conclusions: In the context of this study, neonatal thyroid Background: Infants   32 weeks’ gestation should not dysfunction was seen following exposure to iodine via be exposed to topical iodine and its avoidance is recom- caesarean section but not via exposure to contrast media. mended during pregnancy and breast feeding. Exposure Keywords: Iodine; preterm; thyroid hormones; toxicity. to contrast media and topical iodine is frequently used in many preterm neonates. Aim: To determine whether thyrotropin levels in preterm infants are affected by exposure to intrapartum/neonatal Introduction topical iodine and/or the use of iodinated contrast media. Design: Infants   32 weeks’ gestation were recruited. The iodine requirement for healthy preterm infants is Maternal and neonatal exposures to iodinated contrast estimated, from balance studies, to be 30–40 μg/kg/ media and topical iodine were recorded; levels of thyrotro-