临床化学分析方法：B-Type_Natriuretic_Peptide_NT-proBNP_and_ProBNP.pdfVIP

Kaplan: Clinical Chemistry, 5th Edition Clinical References - Methods of Analysis B-Type Natriuretic Peptide, NT-proBNP and ProBNP Alan H.B. Wu i Name: B-type natriuretic peptide, NT-proBNP, and proBNP Clinical significance: click here Molecular mass: Chemical class: Peptide hormone, prohormone metabolite and prohormone Structure: (See Figure below) The enzymatic cleavage of proBNP into BNP (active hormone, 32 amino acids) and NT-proBNP (inactive peptide, 76 amino acids) by corin. Used with permission from Omland T, Hall C: N- terminal pro-B-type natriuretic peptide. In Wu AHB: Cardiac Markers, ed 2, Totowa, NJ, 2003, Humana Press. See Chapter 28, Physiology of Body Water and Electrolytes, and Chapter 36, Cardiac and Muscle Disease, in the 5th edition of Clinical Chemistry: Theory, Analysis, Correlation. Figure 1 i B-Type Natriuretic Peptide, NT-proBNP and ProBNP New method Fifth edition: Alan H.B. Wu MethodsMethods ofof AnalysisAnalysis ©©byby LawrenceLawrence A.A. KaplanKaplan andand AmadeoAmadeo J.J. Pesce.Pesce. The enzymatic cleavage of proBNP into BNP (active hormone, 32 amino acids) and NT- proBNP (inactive peptide, 76 amino acids) by corin. Used with permission from Omland T, Hall C: N-terminal pro-B-type natriuretic peptide. In: Wu AHB: Cardiac Markers, ed. 2, Totowa, NJ, 2003, Humana Press. Students’ Quick Hyperlink Review • Principles of analysis and current usage • Reference and preferred methods • Interferences • Specimen • BNP, NT-pro BNP and proBNP reference intervals • Interpretation • BNP, NT-pro BNP and proBNP performance goals • References • BNP methods and other tables • Figure Principles of Analysis and