工艺放大过程中需要考虑事项列表process scale up consideration check list.doc

Process scale up consideration check list 工艺放大需要考虑的因素清单 1. purpose 目的: This list is a compilation of the thoughts of the process engineering group. Its purpose is to share ideas from the group with all in an attempt to use the best collective thinking to improve the success of scale up of the process from lab to pilot plant. This does not consider improvements that may be made to the process by changing operations in the process. 这个清单是工艺组的思想汇总。它的目的是通过收集组内最好的思想来提高从实验室到中试车间放大的成功率。这个清单不考虑通过改变工艺的操作的提高。 2. general discussion: 总论 No check list will allow the engineer to successfully scale up the lab process without doing the detailed considerations. 如果不做详细的考虑，没有一个检查清单可以使得工程师将实验室的工艺成功的放大。 An all inclusive checklist might have two questions: 所有包含的清单可能有两个问题 ： - have all important effects been considered? 所有重要影响因数是否已经被考虑到？ - will the conditions of the demonstration run be reproduced well enough in the pilot plant for a successful run. 描述的条件在中试车间中是否能够成功的生产出来？ If the answers to both of these is “Yes”, the scale up should be successful. 如果这两个回答都是“是”，放大时成功的。 3. General effects 通常的影响: As professional chemists and engineers doing the scale up we must make the important judgements needed to be successful. There is never enough time to gather all possible data or to simulate the PP equipment exactly in the lab. Critical judgements must be made.作为资深的化学师和工程师在进行工艺放大时，我们必须做一些重要的判断，而这些判断为成功的工艺放大所必须的。不可能有足够的时间来收集所有可能的数据或者在实验室中来准确的评估中试设备。必须做出关键的评估。 Below is a list of parameters that may be important at any step in the operation: 以下是参数清单，这些参数在运行的每一步中都很重要。 - Time 时间 - Temperature 温度 - PH - pressure/ vacuum 压力/真空 - Materials of construction 材质 - stirring 搅拌 - concentrations 浓度 As you are well aware, combinations of these variables can also be important. In a heterogeneous reaction stirring may have a major effect on reaction rate. In crystallization the rate of cooling may be significant. In most reactions the profile of temperature versus time is rate of cooling may be significant.