强化干预高血压、高脂血症对心脑血管疾患发生率的影响.docVIP

强化干预高血压、高脂血症对心脑血管疾患发生率的影响 强化干预高血压、高脂血症对心脑血管疾患发生率的影响 2010-01-14 唐崇工　刘志隆　李少华　张明　刘悦琴 　　【摘要】　目的　观察强化干预高血压和/或高脂血症对石化企业老职工心脑血管疾患发生率的影响。方法　1990年茂名石化公司全员大体检中大于50岁在职职工4 146人中，检查资料完整者3 916人，其中高血压680人，高血脂673人，高血压合并高脂血症199人，共1 552人，随机分为强化干预组(775人)和一般治疗对照组(777人)，比较两组10年间出现心脑血管终点事件。结果　强化干预组发生心脑血管终点事件比危险因素对照组明显减少(急性心梗发生率为0.9%比1.8%，脑栓塞发生率为4.2%比8.3%，TIA为1.4%比2.4%，P均＜0.01)。石化行业老职工发生危险因素比例较高(34.63%)。结论　对石化行业有心脑血管疾病危险因素者必须积极干预，即使是简单的方法和简单的药物治疗，亦可显著减少心脑血管终点事件的发生。 　　【关键词】　心脑血管疾患　高血压　高脂血症　干预 The effects on morbidity of cardio-cerebrovascular disorders through intervening hypertension and hyperlipemia Tang Songgong, Liu Zhilong, Li Shaohua, et al. （Maoming Petrol Chemical Hospital, Maoming 525011） 　　【Abstract】　Objective　To investigate the effects on morbidities of cardio-cerebrovascular disorders in old staff and workers of petrochemical industry enterprise through intervening hypertension and/or hyperlipidemia. Methods　To find out 1 552 people, included hypertension 680, hyperlipidemia 673, and hypertension associated hyperlipidemia 199 in 3 916 people with complete data from examined 4 146 staff and workers (age＞50 years old) of Maoming Petrol Chemical Company in 1990. They were randomly divided interventional group (775 cases) and control group (777 cases), and cardio-cerebrovascular endpoint events were compared between two groups after following up 10 years.Result　The incidences of cardio-cerebrovascular endpoint events in the interventional group were significantly lower than control group: acute myocardial infarction 0.9% vs 1.8%; cerebral infarction 4.2% vs 8.3%; cerebral hemorrhage 1.4％ vs 3.6%; TIA 1.4% vs 2.4% (P＜0.01). Conclusion　To actively intervene cardio-cerebrovascular risk factors for petrochemical occupation, even using simple method or medicine, could significantly decrease cardio-cerebrovascular endpoint events. 　　【Key words】　Hypertension Cardio-Cerebrovascular disease Hyperlipidemia Intervention 　　依据大型简单随机临床试验的原则，参考有关文献［1］，我们对国家特大型炼油化工企业茂名石油化工公司的老年职工心脑血管疾患主要