Brain age脑的年龄.pptVIP

* Types SDAT VD Scale West 52% 20-48% Asia 20% 68-80% The relationship of scale and age age 85-89Y 90-94Y 95Y AD 20% 32% 41% 64 * 65 * 66 * Hallmark pathological changes for AD * Senile plaques * APP sticks through the neuron membrane. Enzymes cut the APP into fragments of protein, including beta-amyloid. 3. Beta-amyloid fragments come together in clumps to form plaques. 1. 2. 3. Beta-amyloid Plaques: (Amyloid precursor protein (APP) is the precursor to amyloid plaque. * Non-amyloidogenic pathway and amyloidogenic pathway ?-