雷公藤红素缓释滴丸的研究.PDFVIP

网络出版时间：2013-01-09 15:23 网络出版地址：/kcms/detail/12.1108.R1523.003.html 雷公藤红素缓释滴丸的研究 1, 2 2 1, 2* 夏海建 ，张振海 ，贾晓斌 1. 南京中医药大学附属中西医结合医院，江苏 南京 210028 2. 江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室，江苏 南京 210028 摘 要：目的 制备雷公藤红素缓释滴丸，考察药物的分散状态和体外释放度，优化制备工艺。方法 以聚乙二醇4000 （PEG 4000 ）和单硬脂酸甘油酯为载体材料，采用固体分散体方法制备雷公藤红素缓释滴丸，以圆整度和质量差异为评价指标，采 用正交试验考察滴丸成型的影响因素。结果 选择缓释滴丸处方组成为雷公藤红素、单硬脂酸甘油酯和PEG 4000 的质量比 为1 ∶3 ∶7，药料温度80 ℃，滴速20 滴/min ，滴距5 cm，冷凝液温度15 ℃。缓释滴丸中药物以非晶形存在，该缓释滴丸 12 h 的最大累积释放率可达91.2% 。结论 所制得的雷公藤红素缓释滴丸具有良好的缓释效果。 关键词：雷公藤红素；固体分散体；缓释滴丸；体外释放度； 中图分类号：R283.6 文献标志码：A 文章编号：0253 -2670(2013)07 - 0000 - 05 DOI: 10.7501/j.issn.0253-2670.2013.07.000 Studies on sustained-release Dropping Pills of tripterine 1, 2 2 1, 2 XIA Hai-jian , ZHANG Zhen-hai , JIA Xiao-bin 1. Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China 2. Key Laboratory of New Drug Delivery System of Chinese Meteria Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China Abstract: Objective To prepare the tripterine sustained-release dropping pills, investigate its dissolution in vitro and determine the preparation technology. Methods The tripterine sustained-release dropping pills were prepared by solid dispersions method with PEG 4000 and glycerol monostearate as carrier materials. Orthogonal design was conducted to explore the influencing factors of sustained-release dropping pills by evaluating the indexes of roundness and weight difference. Results Th