妈咪爱联合茵栀黄颗粒佐治新生儿病理性黄疸疗效探析.doc

妈咪爱联合茵栀黄颗粒佐治新生儿病理性黄疸疗效分析 　　[摘要] 目的 分析妈咪爱联合茵栀黄颗粒辅助治疗新生儿病理性黄疸的疗效。 方法 方便选取该院2012年1月―2015年12月收治的86例新生儿病理性黄疸患儿，均为高未结合胆红素血症患儿，随机分为观察组和对照组各43例；对照组患儿给予常规治疗，观察组在常规治疗的基础上加用妈咪爱和茵栀黄颗粒口服，用药7 d。测定治疗前后的血清胆红素浓度，比较两组的临床疗效及不良反应发生率。 结果 治疗后观察组血清总胆红素值低于对照组，总胆红素下降幅度高于对照组，P 0.05，差异无统计学意义。 结论 妈咪爱和茵栀黄颗粒治疗新生儿病理性黄疸疗效显著，安全性好，具有重要的临床价值 [关键词] 病理性黄疸；新生儿；妈咪爱；茵栀黄颗粒 [中图分类号] R72 [文献标识码] A [文章编号] 1674-0742（2016）10（c）-0136-03 [Abstract] Objective To analyse the clinical effect on newborns with pathologic jaundice after therapy of Medilac-Vita combind with Yinzhihuang granule. Methods Convenient selection 86 newborns with pathologic jaundice in our hospital from January 2012 to December 2015 were selected， and they were divided into observation group and control group randomly， each of 43 cases.The control group was given conventional therapy； the observation group was given Medilac-Vita combind with Yinzhihuang granule based on the control group lasting for 7 days. Serum bilirubin level of the two groups were tested before and after treatment. Clinical effects and side effects were compared between the two groups.Results After treatment， serum total bilirubin level of the observation group was lower than that of the control group， and it was declined higher than that of the control group； There was a significant difference between the two groups （P 0.05）. Conclusion Medilac-Vita combind with Yinzhihuang granule in treatment of neonatal pathologic jaundice is effective and safe， and it also has important clinical value. [Key words] Pathologic Jaundice； Newborns； Medilac-Vita； Yinzhihuang Granule 新生儿病理性黄疸是新生儿科的常见病。该院诊治的新生儿病理性黄疸以高未结合胆红素血症居多。未结合胆红素对脑细胞有不良反应。部分高未结合胆红素患儿可发生核黄疸，又称胆红素脑病，重者死亡，存活者多留有神经系统后遗症。有时虽然近期临床未出现明显核黄疸症状，但是2～3个月后仍可能出现神经系统后遗症[1]。高胆红素血症干预的目的即是预防重度高胆红素血症和胆红素脑病的发生[2]。2012年1月―2015年12月，该院采用妈咪爱和茵栀黄颗粒口服辅助治疗新生儿病理性黄疸43例，取得了满意的疗效，现报道如下 1 资料与方法 1.1 一般资料 方便选取的86例新生儿病理性黄疸，均为同期该院儿科病房收治的高未结合胆红素血症患儿，随机分为观察组和对照组各43例；观察组中男22例，女21例，体重（3.28±0.36）kg，胎龄（39.3±1.8）周，日龄3～28 d，平均（10.2±3.6）d，病因：感