异基因外周血造血干细胞移植治疗重型再生障碍性贫血.pdfVIP

2009 32 2 # 121 # # # 章卫平 付利 王健民 侯军 宋献民 周虹 = ( allo-PBSCT ) ( SAA) 10 allo-PBSCT SAA , 8 , 2 5 , 18~ 42 , 27 3 SAA( SAA- Ñ) , 2 ; 7 SAA( SAA- Ò) , ( CsA) 1~ 240 , 12 T ( AT G) + ( CTX) : - 5~ - 1 d AT G 4~ 5 Lg # kg- 1 # d- 1 , - 4 d~ - 3 d CT X 0 mg # kg- 1 # d- 1 ; CsA+ ( MTX) ( GVH D) 9 9 , \0. 5@ 10 / L \20 @ 10 / L + 13. 2 d( + 11~ + 15 d) + 14. 3 d( + 13~ + 15 d) 8 ; 2 , 1 1 , 1 3 , DNA ( ST R-PCR ) , 1ÒGVH D, 2 GVHD3 , 3~ 92 , 33 , 10 SAA AT G+ CT X allo-PBSCT SAA, , = ; ; ; Allogeneic peripheral blood hemat opoiet ic st em cell t ransplant at ion for severe aplast ic anemia ZHANG Weiping , FU Li , WANG Jianmin , HOU Jun , SONG Xianmin , ZHOU Hong . Department of Hematology , Changhai Hospital, Second Military Medical University , Shanghai 200433, China Corresponding author : ZHANG Weiping . E-mail : zhangwp @medmail. com . cn = Abst ract Object ive To evaluate the efficacy of allogeneic peripheral blood hematopoietic stem cell transplantation (allo-PBS T) for severe aplastic anemia (SAA) . Met hods Ten patients withSAA (three were diagnosed as SAA-Ñ and seven as SAA-Ò, with two complicated with severe infection) received allo-HS T, including eight receiving from related and two from unrelated donors. The patients included five men and five women, witha medianage of 27 years old (range: 18- 42) . Most of patients inour groupwere treatedwith sA a