急性肺损伤_急性呼吸窘迫综合征患者凝血纤溶系统的变化_叶伶.pdf

( ) Fudan Univ J Med Sci 2008 Sep,35(5) 67 1 / v 叶 伶 金美玲 徐晓波 高 磊 白春学 朱 蕾 ( 200032) = / (acute lung injury/acute respiratory distress syndro e, ALI/ ARDS) C( protein C, PC) PC( thro bo odulin,T M) -1( plas inogen activator inhibitor-1, PAI-1) , ALI/ARDS ALI/ ARDS ( 24 ) ( 12 ) ( ELISA) PCTMPAI-1, PC ALI/ARDS APACHE Ò( ultiple organ dysfunction syndro e,MODS)ALI/ARDS ALI/ ARDS PC PC ( P 0. 01,P 0. 05); TMPAI-1(P 0. 01) ALI/ARDS PC APACHE Ò MODS (P 0.01) ;ALI/ ARDS PAI-1 (P 0. 01,P 0. 05) ALI/ARDS PCTM PC MODS (P 0.01) ; PCTMPAI-1 PC , PCTMPAI-1 ALI/ ARDS , ; = ; ; ; C; ; -1 = R 563. 8 = B The changes of coagulation and fibrinolysis system in acute lung injury/ acute respiratory distress syndrome v YE Ling, JIN Me-i ling , XU Xiao-bo, GAO Lei, BAI Chun-xue, ZHU Lei (Dep artment of Resp iration, ZhongShanH osp ital, Fudan Univ ersity , Shanghai 200032, China) =Abstract Objective To explore the influence of acute lung injury/ acute respiratory distress syndro e ( ALI/ ARDS) on coagulation and fibronolysis syste by exa ining the plas a levels of protein C (PC) , thro bo odulin (TM) and plas inogen activator inhibitor-1 (PAI-1) . Methods The study was divided into two groups: ALI/ ARDS patients (n= 24) and nor al volunteers (n= 12) . The plas a levels of PC antigen, TM antigen and PAI-1 antigen were deter ined by enzy e-linked i unosorbent assay (ELISA) . The plas a level of active PC (APC) was deter ined by chro ogenic substrate et