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6058 • The Journal of Neuroscience, May 13, 2009 • 29(19):6058–6067 Cellular/Molecular Estradiol Reverses a Calcium-Related Biomarker of Brain Aging in Female Rats Lawrence D. Brewer,* Amy L. S. Dowling,* Meredith A. Curran-Rauhut, Philip W. Landfield, Nada M. Porter, and Eric M. Blalock Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536 An increase in L-type voltage-gated calcium channel (LTCC) current is a prominent biomarker of brain aging and is believed to contribute to cognitive decline and vulnerability to neuropathologies. St