不同剂量瑞舒伐他汀对冠心病合并高胆固醇血症患者血脂和血.PDF

不同剂量瑞舒伐他汀对冠心病合并高胆固醇血症患者血脂及血清高敏 C 反应蛋白的影响 王贵鹏，曹桂秋(新疆医科大学第五附属医院心内科，乌鲁木齐 830011) 摘要：目的 对比不同剂量瑞舒伐他汀对冠心病(CAD)合并高胆固醇血症(HC)患者血脂及血清高敏 C 反应蛋白(HS-CRP) 的影响，并评价其量效关系。方法 将 60 例 CAD 合并 HC 患者随机分为常规剂量组(10 mg·d1 ，C 组)和大剂量组(40 mg·d1 ， H 组) ，各 30 例，分别测定服用相应剂量瑞舒伐他汀前及 1 个月后 HS-CRP 、血脂各成分及一般生化指标，并对 2 组结果 加以比较。结果 治疗前 2 组间各指标均无差异，治疗 1 个月后 2 组 LDL-C 、TC、HS-CRP 均较治疗前降低(P0.05) ，H 组较 C 组降低更为明显(P0.05) 。LDL-C 、TC 下降与 HS-CRP 下降呈较显著正相关(P0.01) 。结论 瑞舒伐他汀可明显 降低 CAD 合并 HC 患者血脂及 HS-CRP 水平，大剂量较常规剂量更为有效，降脂与降低 CRP 作用具有较好的相关性。 关键词：瑞舒伐他汀；冠心病；C 反应蛋白；高胆固醇血症 中图分类号：R969.4 文献标志码：B 文章编号：1007-7693(2010)13-1166-04 Effect of Rosuvastatin with Different Doses on C-Reactive Protein and Blood-Fat in Patients Suffered from Coronary Artery Disease and Hypercholesteremia WANG Guipeng, CAO Guiqiu(Department of Cardiology, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China) ABSTRACT: OBJECTIVE To investigate the level of high sensitivity C-reactive protein(HS-CRP) and blood-fat in patients suffered coronary artery disease with hypercholesteremia and the effect of rosuvastatin with different doses on it. METHODS Sixty patients with CAD and HC were assigned into common dose group(10 mg·d1, C group) and high dose group(40 mg·d1, H 作者简介：王贵鹏，女，硕士生，主治医师 Tel: (0991)7923436 E-mail: caoguiqiu@ ·1166 · Chin JMAP, 2010 July, Vol.27 No.13 中国现代应用药学2010 年 7 月第 27 卷第 13 期 group), everyone was detected the level of HS-CRP and TC, TG, LDL, HDL before and 1 month after treated with rosuvastatin. RESULTS The level of CRP, LDL-C, TC was much reduced in both the two groups after therapy (P0.05), while that of H group was even lower than C group (P0.05). The change of CRP and LDL-C, TC showed a significant correlation (P0.01). CONCLUSION Rosuvastatin can reduce the level of CRP and LDL, TC obviously. Besides, the effect sh