2种不同宫颈癌新辅助化疗方案临床疗效及化疗不良反应比较.pdf

CHINESECOMMUNITY DOCTORS 论著·临床论坛 2种不同宫颈癌新辅助化疗方案临床疗效及化疗不良反应比较 胡钧文 田源 644000宜宾市第三人民医院肿瘤科 doi:10.3969/j.issn.1007-614x.2017.5.40 摘 要 目的：比较2种不同宫颈癌新辅助化疗方案临床疗效及化疗不良反应。方法：收治ⅠB2期～ⅡA2期宫颈癌 患者42例，随机分为两组。A组给予长春新碱、顺铂、博莱霉素治疗，B组给予顺铂、紫杉醇治疗，比较两组疗效、 化疗前后肿瘤体积、不良反应情况。结果：两组治疗总有效率比较，差异无统计学意义(P＞0.05)。两组治疗后平均肿 瘤体积明显小于治疗前(P＜0.05)，两组治疗后平均肿瘤体积比较，差异无统计学意义(P＞0.05)。两组不良反应发生率 比较，差异无统计学意义(P＞0.05)。结论：2种不同宫颈癌新辅助化疗方案均可用于临床治疗。 关键词 宫颈癌；新辅助化疗；临床疗效；不良反应 Comparisonofclinicaleffectandadversereactionsbetweentwodifferentneoadjuvantchemotherapyregimensfor cervicalcancer HuJunwen,TianYuan DepartmentofOncology,theThirdPeoplesHospitalofYibinCity644000 Abstract Objective:Tocomparetheclinicaleffectandadversereactionsoftwodifferentneoadjuvantchemotherapyregimensfor cervicalcancer.Methods:42casesofpatientswithstage ⅠB2～ⅡA2ofcervicalcancerweredividedintotwogroupsrandomly.A groupwastreatedwithvincristine,cisplatin,bleomycin.Bgroupwastreatedwithcisplatinandpaclitaxel.Theclinicaleffect,tumor volumestatusbeforeandafterchemotherapy,adversereactionbetweengroupswerecompared.Results:Therewasnosignificant difference of the total effective rate between groups (P＞0.05).The mean tumor volume of two groups after treatment was significantlysmallerthanthatbeforetreatment(P＜0.05).Therewasnosignificantdifferenceofmeantumorvolumebetween groups(P＞0.05).Therewasnosignificantdifferenceoftheincidenceofadversereactionsbetweengroups(P＞0.05).Conclusion: Thetwokindsofneoadjuvantchemotherapyforcervicalcancercouldbeusedinclinicaltreatment. Keywords Cervicalcancer;Neoadjuvantchemotherapy;Clinicalefficacy;Adversereaction 宫颈癌是一种女性常见的恶性肿 个疗程，连续治疗2个疗程。B组在 B组为66.67%(14例)。两组治疗总有效率 瘤，数据显示其发病率以及死亡率均处 术前经静脉给药治疗，第2天静脉滴 比较，差异无统计学意义(P＞0.05)。见 [1]