25-羟维生素D和儿童1型糖尿病和酮症酸中毒的相关性研究.PDFVIP

25-羟维生素D 与儿童1 型糖尿病及酮症酸中毒的相关性研究 高真(长兴县人民医院儿科，浙江 湖州 313100) 摘要：目的 探讨血清25-羟维生素D[25-(OH)D]水平与儿童1 型糖尿病及酮症酸中毒(DKA)的相关性。方法 选取2006 年 1 月—2009 年 12 月在本院治疗的152 例患儿，其中52 例为首次发病的 1 型糖尿病患儿，其余 100 例按糖尿病标准排 除糖尿病。对52 例 1 型糖尿病患儿的临床和实验室资料进行研究，分析血清25-(OH)D 水平与儿童1 型糖尿病及酮症酸 中毒的关系。结果 1 型糖尿病儿童血清25-(OH)D 的平均水平为(63.67±28.41)nmol·L1 ，显著低于非糖尿病儿童(P0.05) ， 差异有统计学意义。DKA 患儿的血清25-(OH)D 的平均水平为(58.63±27.79)nmol·L1 ，显著低于非DKA 患儿(P0.05) ， 差异有统计学意义。结论 血清 25-(OH)D 的水平较低可能会增加儿童1 型糖尿病以及发生酮症酸中毒的风险。 关键词：1 型糖尿病；儿童；酮症酸中毒；25-羟维生素D 中图分类号：R969.4 文献标志码：B 文章编号：1007-7693(2012)05-0466-03 Correlation between Serum 25-(OH)D Levels and Children with Type 1 Diabetes Mellitus and Diabetic Ketoacidosis(DKA) GAO Zhen(Department of Pediatrics, Changxing People’s Hospital, Huzhou 313100, China) ABSTRACT: OBJECTIVE To investigate the correlation between levels of serum 25-(OH)D and children with type 1 diabetes mellitus and diabetic ketoacidosis(DKA). METHODS Fifty-two cases who initially fell ill with type 1 diabetes mellitus were selected from 152 cases who stayed in our hospital from January 2006 to November 2009. The other 100 children were excluded from type 1 diabetes mellitus according to following standard. Clinical and laboratory data of 52 cases with type 1 diabetes mellitus was studied. The relationship between levels of serum 25-(OH)D and children with type 1 diabetes mellitus and DKA was acquired. RESULTS The serum 25-(OH)D level of children with type 1 diabetes mellitus was(63.67±28.41)nmol·L1 which was significantly lower than that excluded from type 1 diabetes mellitus(P0.05). The average serum 25-(OH)D level of DKA children was (58.63±27.79)nmol·L1 which was statistically lower than non-DKA cases. CONCLUSION The low level of serum 25-(OH)D maybe increase the risk of development of type 1 diabetes mellitus and DKA. KEY WORDS: type 1 diabetes mellitus; children; diabetic ketoacidosis; 25-(OH)D