7.2 染色体畸变-数目改变.pptVIP

Down Syndrome and Maternal Age As maternal age increases, the risk of having a baby with Down syndrome increases At age 20 less than 1 in 1000 births results in down syndrome After age 40, greater than 1 in 100 births results in Down syndrome Trisomy 18: Edward’s Syndrome (47,+18) small at birth, very slow growing, mental retardation, malformed feet, heart malformations. For unknown reasons, 80% of live born trisomy 18 babies are female. Trisomy 13: Patau Syndrome (47,+13) Facial malformations, eye defects, extra fingers or toes, feet with protruding heels, malformations of the brain, nerv