用于心血管医疗装置的聚合物材料表面构建与生物相容性评价：聚合物生物材料表面的内皮细胞组织工程化改性.doc

Surface construction and biocompatibility of polymer materials as cardiovascular devices: modified tissue-engineered endothelial cells on the surface of polymeric biomaterials Chen Bao-lin1, Wang Dong-an2, 3 1 Bureau of Science & Technology Research, Hulunbuir College, Hulunbuir 021008, Inner Mongolia Autonomous Region, China 2 Institute of Polymer Science, Zhejiang University, Hangzhou 310027, Zhejiang Province, China 3 Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA Cite this article: Chen BL, Wang DA. Surface construction and biocompatibility of polymer materials as cardiovascular devices: modified tissue-engineered endothelial cells on the surface of polymeric biomaterials. Zhongguo Zuzhi Gongcheng Yanjiu. 2016;20(30):4515-4523. DOI:10.3969/j.issn.2095-4344.2016.30.016 ORCID: 0000-0001-8283-783X(Chen Bao-lin) Abstract BACKGROUND: As the cardiovascular device, biomaterials applied under the blood-contact conditions should have anti-thrombotic, anti-biodegradable and anti-infective properties. OBJECTIVE: To review the research progression in polymer materials for implantation and intervention in cardiovascular tissue engineering and to explore the biocompatibility, blood compatibility and cytocompatibility of the surface-modified polymer biomaterials based on the surface endothelialization using tissue engineering techniques. METHODS: We retrieved PubMed and Wanfang databases for relevant articles publishing from 1963 to 2015. The key words were “Biocompatibility, Blood compatibility, Biomedical Materials, Biomedical polymer materials” in English and Chinese, respectively. Those unrelated, outdated and repetitive papers were excluded. Literatures addressing the blood compatibility, biocompatibility, and cytocompatibility of the surface-modified polymer biomaterials based on the surface endothelialization using tissue engineering techniques were investigated by summarizing function of vascu