局部应用丝裂霉素预防声带粘连.PDFVIP

中国耳鼻咽喉头颈外科/2007年5月,第14卷,第5期 论 著 局部应用丝裂霉素预防声带粘连 韩红蕾，杨大章，刘剑峰，喻妮 （卫生部中日友好医院耳鼻咽喉科，北京　100029） [摘 要]　目的　探讨丝裂霉素在预防声带术后声带粘 [ABSTRACT]　OBJECTIVE　To investigate the effect of 连、狭窄中的作用。方法　将56例声带病变患者随机分 topical application of mitomycin on the prevention of glottic 为2组：单纯手术组仅行支撑喉镜下声带病变切除术， adhesion and stenosis after transoral microresection 手术加丝裂霉素组在行支撑喉镜下声带手术后，局部辅 of glottic lesions involving the anterior commissure. 以丝裂霉素。术后对患者进行随访并评价其临床效果。 METHODS　Fifty-six patients were randomly divided into 结果　单纯手术组，术后有12例 （42 .86 % ）出现不 two groups. The patients in the 1st group were treated 同程度的声带粘连；手术加丝裂霉素组，术后仅有5例 by transoral microresection alone. And the patients in the （17.86 %）出现轻度的声带粘连。两组间差异具有显 2nd group were treated by both transoral microresection 著性 （P ＝0.0220.05）。结论　局部应用丝裂霉素可以 and topical application of mitomycin. The clinical outcome 预防和减少声带术后声带粘连，可作为声带术后的辅助治 was compared. RESULTS　There were 12 patients in 疗方法之一。 the 1st group who had varied anterior glottic adhesion, [关键词]　丝裂霉素；声带；缩窄，病理性 while only 5 patients in the 2nd group had mild anterior glottic adhesion. The difference between the two groups Prevention of glottic adhesion by topical application was significant. CONCLUSION　Topical application of of mitomycin mitomycin can prevent and decrease glottic adhesion HAN Honglei, YANG Dazhang, LIU Jianfeng, YU Ni and stenosis after glottic operation. Topical application of (Department of Otolaryngology, China-Japan Friendship mitomycin can be used as an adjuvant treatment of glottic Hospital, Beijing, 100029, China) lesion. Corresponding author: YANG Dazhang (Email: [Key words]　Mitomycin; Vocal Cords; Constriction, yangdazhang2000@)