肿瘤分子生物学3细胞永生化与肿瘤发生.pptVIP

Page * Telomere and bone marrow collapse of dyskeratosis congenita X-linked form of the disease, a protein known as dyskerin is absent or malfunctioning. Dyskerin associates with the telomerase-associated RNA subunit (hTR) and helps hTR to assemble in the telomerase holoenzyme. An autosomal dominant version of the same disease is caused by the inheritance of a defective hTR-encoding gene. Cells in proliferating tissues of affected individuals exhibit dicentric chromosomes,which are indicative of interchromosomal fusions. Page * ●培养细胞无限增殖的障碍: 衰老/危象 (senescence and crisis)； 衰老指的是培养细胞