DUR及DUE方法在社区获得性肺炎患者用药情况评价中应用效果.doc

DUR及DUE方法在社区获得性肺炎患者用药情况评价中应用效果 　　[摘要]目的 评估药物利用评价（DUR）与药物利用评估（DUE）方法在社区获得性肺炎患者用药情况评价中的应用效果。方法 通过DUR以及DUE的方法，对广州市天河区人民医院2015年1月～2016年8月呼吸科治疗出院的107例社区获得性肺炎患者的相关用药情况进行综合分析。结果 患者治疗采用的抗菌药共21种，其中5种药物的DUI1，分别为注射用头孢呋辛钠、头孢他啶、阿莫西林分散片、伊曲康唑胶囊、头孢吡肟。评估结果为处方量过大，存在用药不合理的现象。对入院患者进行治疗的过程中，有7例出现药物不良反应，经过治疗后96.3%的患者出现明显好转。另有4例患者放弃住院治疗。结论 联合使用DUR和DUE法能够更加全面地对基层医院的抗菌药使用进行评价，及时发现不合理用药现象，促进药品资源的管理，促使医院建立和完善用药体系 [关键词]社区获得性肺炎；药物利用评价；药物利用评估；抗菌药 [中?D分类号] R563.1+9 [文献标识码] A [文章编号] 1674-4721（2017）02（b）-0149-03 [Abstract]Objective To evaluate the application effect of DUR and DUE in the evaluation of drug use in patients with community acquired pneumonia.Methods 107 patients with community acquired pneumonia treated in Department of Respiration of People′s Hospital of Tianhe District in Guangzhou City from January 2015 to August 2016 were comprehensively analyzed by DUR and DUE.Results A total of 21 antimicrobial agents were used in the treatment of patients，and drugs DUI of 5 cases were more than 1，which were Cefuroxime Sodium，Ceftazidime，Amoxicillin Dispersible Tablets，Itraconazole Capsules and Cefepime.The evaluation results showed that prescription were too large and drug used were irrational.7 patients had adverse drug reactions in the process of hospitalization，96.3% of the patients showed obvious improvement after treatment.Another 4 patients abandoned hospitalization.Conclusion The combined used of DUR and DUE can evaluate the use of antimicrobial agents in primary hospitals more comprehensively，discover unreasonable drug use，promote the management of drug resources，and promote the establishment and perfection of hospital drug system. [Key words]Community-acquired pneumonia；Drug use review；Drug use evaluation；Antimicrobial 社区获得性肺炎是一种常见的肺部感染疾病，是患者在医院外罹患的肺部实质炎症。依据临床表现不同，分为典型肺炎和非典型肺炎，两种类型的肺炎在病原学一级药物的选择治疗方面有所不同[1]。随着抗菌药物使用量的加大、社会老龄化的日益加重、病原体不断变迁以及不合理用药现象等原因，即使在疫苗免疫以及应用强效抗生素的条件下，部分肺炎患者的治疗效果仍不理想，这使得社区获得性肺炎的威胁日益严重，因此需要对社区获得性肺炎患者抗菌药的使用进行有效评估。药物利用评价（DUR）和药物利用评估（DUE）在目前医药服务中应用较为广泛[2]。本