免疫组化的临床意义(国外英文资料).docVIP

免疫组化的临床意义(国外英文资料) The significance of the clinical common immunohistochemical index Clinical work, we used to immunohistochemical drug-resistant tumor cells prognostic marker, but many units only write a positive result, dont write clinical significance, the result of clinical wouldnt help very much, because many of the doctors dont know the meaning of these results, it is recommended that when everyone in a such a report, the immunohistochemical drug-resistant tumor cells prognostic marker the meaning of the print in the report, in order to increase the pathological report of use value. 1, the prognosis of malignant tumors immunohistochemical resistant tag, a full set of four: P - gP, GST PI, TOPO Ⅱ, Ki - 67. 2, immunohistochemical drug-resistant breast cancer prognosis markers, a full set of seven: P - gp, GST PI, TOPO Ⅱ, Ki - 67, ER, PR, C - erbB - 2. Meaning: markers -- roles -- positive parts -- clinical meaning Multi-resistant genes protein pump (P - Gp) - medicines - membrane/cytoplasm - the higher positive rate, for the following drug resistance: the more doxorubicin, soft erythromycin, tables, doxorubicin, mitoxantrone, VLB, vincristine, violet alcohol, taxol emperor. GuGuangGan peptide S transferase (GST PI) - detoxification, cytoplasm, the higher the positive rate, for the following drug resistance: the more doxorubicin and cisplatin, nitrogen mustard, cyclophosphamide, tumor can be better. Topoisomerase Ⅱ (TOPO Ⅱ) - targets role - the nucleus - the higher positive rate, the more effective for drugs in the following: anthracycline-based antibiotics and ghost mortar toxins, such as for neper VP16, glycosides, rose tree alkali, neomycin, soft erythromycin, tables, doxorubicin, adriamycin, VM26. The high sex ratio is particularly effective for VP16. Estrogen receptor (ER) - the sex hormone - the cytokine - the higher the positive, the more effective the tumor is for endocrine therapy, and the better the prognosis. Progesterone receptor (PR) - the sex hormone