药英整理的重.docVIP

Unit 5 Lead compounds Words: lead compound[not intended to be used as a clinical agent临床药物,is a starting point], agonist[激动剂], antagonist[拮抗剂], chemical modification, high-throughput screening(HTS)[高通量药物筛选 ], target[靶点] Knowledge points(选择 判断) How to understand “lead compound is the starting point from which a clinically(临床的) useful compound can be developed?”先导化合物是发展研发临床有效化合物的起点。 The tests to detect a lead compound can reveal effects on different levels. 检测先导化合物测试可以揭示在不同水平的影响. 【A physiological（生理学的） effect, a cellular（细胞学的） effect, a molecular（分子的） effect.】 Agonist is used as a lead compo