HCG日血清激素水平对供精体外受精妊娠结局的影响.docVIP

HCG日血清激素水平对供精体外受精妊娠结局的影响 刘芳，李丽,王兴玲*，王婧彦，，冯涵琪 郑州大学第三附属医院生殖医学中心 (河南 郑州) 450052 【摘要】目的：探讨在控制性超排卵（COH）过程中人绒毛膜促性腺激素（human chorionic gonadotropin HCG）注射日激素水平与供精体外受精-胚胎移植(in vitro fertilization and embryo transfer with donor seman，IVF-D /ICSI-D)结局的关系。方法：回顾性分析2007年12月至2011年10月在我中心行IVF-D或ICSI-D助孕的157例患者170个取卵周期资料，比较妊娠组及非妊娠组HCG日激素水平与妊娠结局的相关性，并根据HCG日孕酮（P）μg/L组及P＞0.9μg/L组，比较两组间的各项指标变化。结果：妊娠组HCG日孕酮水平明显低于未妊娠组，差异有统计学意义（p＜0.05）；P＞0.9μg/L组较P≤0.9μg/L组HCG日血清E2水平、获卵率升高(p＜0.05)，而可利用胚胎率、优质胚胎率降低(p＜0.05)，胚胎种植率和临床妊娠率明显降低，差异有统计学意义（p＜0.05）；两组受精率、卵裂率及冻融胚胎移植周期临床妊娠率差异无统计学意义(p＞0.05)。结论：HCG日孕酮水平一定程度上影响卵子质量及子宫内膜容受性，根据HCG日P值可有效预测供精体外受精胚胎移植的妊娠结局。 【关键词】：HCG,孕酮水平，供精体外受精-胚胎移植，妊娠结局 中国图书分类号 文献标识码 文章编号 Impact of progesterone level on the day of Human chorionic gonadotropin administration on outcome of in vitro fertilization with donor seman Liu Fang, Lili,Wang Xingling,Wang Jingyan,Feng Hanqi Reproductive Center of the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052,Henan, China 【Abstract】Objective:To discuss the impact of hormone level on the day of human chorionic gonadotropin administration on pregnancy outcome of in vitro fertilization and embryo transfer with donor seman in controlled ovarian hyperstimulation. Methods: Retrospective analysis the information of 157 patients of 170 fresh cycles ,who had received IVF-D/ICSI-D in our reproductive medical centre from December 2007 to October 2011.And firstly, the patients were divided into two groups according to the pregnancy outcome, pregnancy group and non-pregnancy group. compare the relevance of the pregnancy outcome of this two groups, hormone level on the day of HCG. then secondly,the patients were divided into two groups according to serum progesterone level on the day of HCG administration .Group A:P≤0.9μg/L 47 cycles, Group B:P＜0.9μg/L 59 作者简介：刘芳（1986-），女，河南开封人，在读硕士生，研究方向：生殖医学,E-mail:lfzdw1223@163.com 通讯作者：王兴玲（1962-），主任医师，E-mail:wangxl20@. cycles. compare the various