奥美拉唑及泮托拉唑治疗上消化道出血临床效果及安全性对比.doc

奥美拉唑及泮托拉唑治疗上消化道出血临床效果及安全性对比 　　[摘要] 目的 探讨奥美拉唑与泮托拉唑治疗上消化道出血的临床效果及安全性。方法 便利选择该院2016年2―11月收治的32例上消化道出血患者为研究对象，以随机数字表法分组，A组16例接受泮托拉唑治疗，B组16例接受奥美拉唑治疗，对两组患者疗效及出血情况、临床指标进行观察。结果 A组治疗总有效率为93.75%，B组为87.50%，?勺椴钜煳尥臣蒲б庖澹?P0.05）；A组治疗后第1天、第2天、第3天的出血量分别为（161.54±11.82）mL、（101.32±5.68）mL、（13.61±4.18）mL，均较B组低，差异有统计学意义（P0.05）。结论 奥美拉唑与泮托拉唑治疗上消化道出血均有良好效果及安全性，但是泮托拉唑可快速控制出血量，缩短出血时间，更具有推广价值 [关键词] 奥美拉唑；泮托拉唑；上消化道出血；疗效 [中图分类号] R573.2 [文献标识码] A [文章编号] 1674-0742（2017）02（b）-0109-03 [Abstract] Objective To discuss the clinical effect and safety of omeprazole and pantoprazole in treatment of upper gastrointestinal hemorrhage. Methods Convenient selection 32 cases of patients with upper gastrointestinal hemorrhage admitted and treated in our hospital from February to November 2016 were selected as the research objects and randomly divided into two groups with 16 cases in each， the group A were treated with pantoprazole， while the group B were treated with omeprazole， and the curative effect， bleeding and clinical indexes of the two groups were observed. Results The difference in the total effective rate between the group A and the group B had no statistical significance（93.75% vs 87.50%），（P0.05）， and the bleeding amount at 1 d， 2 d and 3 d after treatment in the group A was respectively （161.54±11.82）mL，（101.32±5.68）mL，（13.61±4.18）mL， which were lower than those in the group B， and the differences had statistical significance（P0.05）. Conclusion The effect and safety of omeprazole and pantoprazole in treatment of upper gastrointestinal hemorrhage is good， but the pantoprazole can rapidly control the bleeding amount and shorten the bleeding time， which is worth promotion. [Key words] Omeprazole； Pantoprazole； Upper gastrointestinal hemorrhage； Curative effect 上消化道出血是消化科常见急重症，其死亡率达5%～10%[1]，随患者年龄增长而上升，伴有肝肾功能障碍或心脏疾病患者致死风险更高。上消化道出血发生原因复杂，多数为消化性溃疡所致，若未及时采取措施控制病情发展，极可能威胁患者生命安全。泮托拉唑与奥美拉唑均为治疗上消化道出血的常用药物，但是对于两者应用于上消化道出血治疗中优劣性尚未明确。该研究对该院2016年2―11月收治的32例上消化道出血患者进行对比，探讨泮托拉唑与奥美拉唑的治疗效果，现报道如下 1 资料与方法