他汀与葡萄膜炎.pdfVIP

Association Between Statin Use and Uveitis: Results From the Pacific Ocular Inflammation Study DURGA S. BORKAR, VIVIEN M. THAM, ELIZABETH SHEN, JOHN V. PARKER, AILEEN UCHIDA, ALELI C. VINOYA, AND NISHA R. ACHARYA PURPOSE: To assess whether there is a protective asso- race, and autoimmune diseases, the odds of a statin user ciation between statin use and uveitis diagnosis. developing uveitis were 48% less than the odds of a DESIGN: Retrospective, population-based case-control non–statin user developing uveitis (OR: 0.52, 95% CI: study. 0.29–0.94, P [ .03). Similarly, the odds of developing METHODS: Medical records of all patients in the Kaiser uveitis were 33% less for statin users compared to non– Permanente Hawaii health plan between January 1, 2006 statin users (OR: 0.67, 95% CI: 0.38–1.19, P [ .17) and December 31, 2007 (N [ 217 061) were searched when adjusting for these factors and using the ophthal- electronically for International Classification of Diseases, mology clinic control group. 9th Revision, diagnosis codes related to uveitis. Chart re- CONCLUSIONS: Statin use may be protective against view was done to confirm incident uveitis diagnosis dur- the development of uveitis. Several anti-inflammatory ing the study period. Two control groups were each and immunomodulatory mechanisms may explain this randomly selected at a 5:1 ratio to cases, and controls association. (Am J Ophthalmol 2015;159:707–713. were assigned an index date to match their respect