低频超声促渗研究进展_任瑞雪.pdfVIP

专题 · 超声 Thematic Forum · Ultrasound 低频超声促渗研究进展 1 2 1 1 任瑞雪 韦永梅 郑驰超 彭虎 1 合肥工业大学 （合肥230002 ） 2 阜阳师范学院 （阜阳236032 ） 文章编号：1006-6586(2015)06-0006-06 中图分类号：R445.1 文献标识码：A 收稿日期： 内容提要：低频超声促渗是经皮给药的重要方法之一，其主要机制是超声空化作用通过改变角质层 2015-03-20 脂质排列结构并形成水性通道来提高皮肤渗透性。近年来低频超声促渗相关的实验研究 基金项目： 越来越多，本文围绕着超声促渗的机制、影响因素、超声与其他经皮给药技术联合应 国家自然科学基金 用、安全性等方面，介绍了低频超声促渗的研究进展，并对双频超声经皮渗透这一新的 青年科学基金( 批 超声促渗技术给予了介绍。 准号 和国家自然科学 关键词： 低频超声 超声促渗 经皮给药 空化效应 双频超声 基金（批准号： DOI:10.15971/j.cnki.cmdi.2015.06.002 资助。 The Progress of Research on Low-frequency Sonophoresis REN Rui-xue1 WEI Yong-mei2 ZHENG Chi-chao1 PENG Hu1 1 Hefei University of Technology (Hefei 230002) 2 Fuyang Teachers College (Fuyang 236032) Abstract: Low-frequency sonophoresis is one of the important methods of transdermal drug delivery. The main mechanism is ultrasonic cavitation, which can improve the penetration of skin by altering the arrangement structure of cells and forming a water channel in stratum corneum. In recent years, the experimental study of low-frequency sonophoresis is becoming more popular. This article focus on the mechanism and influence factors of sonophoresis, combination of ultrasound and other transdermal drug delivery technologies, the safety and other aspects to introduce the progress of research on low-frequency sonophoresis. The dual frequency sonophoresis as a new ultrasonic penetration technology is also introduced. Key words: low frequency ultrasound, sonophoresis, transdermal drug delivery, cavitation effect, dual