ERK传导通路及中枢神经系统疾病.PDFVIP

第10卷第5 期 Vol.10 No.5 2017 年3 月 March 2017 ERK 传导通路与中枢神经系统疾病 迟春玲，刘 彬* （哈尔滨医科大学附属第四医院神经内科，哈尔滨 150001 ） 摘要：细胞外信号调节激酶（extracellular signal regulated kinase ，ERK ）是丝裂原活化蛋白激酶（mitogen activated protein kinase ，MAPK ）家族的一员，在将细胞外信号传给细胞元的反应中起重要作用，广泛地参与复杂的生 理病理过程。在中枢神经方面，目前研究发现ERK 传导通路不仅在学习和记忆的形成中发挥重要作用，而且 也参与了脑缺血、阿尔茨海默病（Alzheimer’s disease ，AD ）、帕金森病（Parkinson’s disease ，PD ）、肌萎缩侧 索硬化（amyotrophic lateral sclerosis ，ALS ）、癫痫等中枢神经系统常见疾病的发病过程。这里将重点阐述ERK 传导通路在中枢神经系统疾病中的国内外最新研究进展。 关键词：神经病学；ERK 传导通路；综述；生物学作用 中图分类号：R741.02 文献标识码：A 文章编号：1674-2850(2017)05-0471-06 Role of ERK pathway in central nervous system diseases CHI Chunling, LIU Bin (Department of Neurology , The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China) Abstract: Extracellular signal regulated kinase (ERK) is one of mitogen activated protein kinase (MAPK), and it plays an important role in transmitting the extracellular signals to the cell, and widely involves in the complex physiological and pathological processes. In the central nervous system, the present study found that the ERK pathway not only played an important role in learning and memory formation, but also involved in many common central nervous system diseases such as cerebral ischemia, Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and epilepsy. This article will focus on the latest research progress of ERK pathway in the central nervous system diseases. Key words: neurology; ERK pathway; review; biological function 0 引言 ERK 是MAPK 家