泌尿生殖系统支原体感染和耐药性研究.docVIP

泌尿生殖支原体感染及耐药性研究 张利红 施芳 （湖北省黄石市中医医院检验科，湖北 黄石 435000）摘要目的湖北省黄石市中医医院2009年1月2010年6月间泌尿生殖道支原体感染状况及其药物敏感情况，并进一步探讨其耐药性变化，为临床合理用药提供参考。方法 采用珠海银科医学工程有限公司提供的支原体培养试剂盒进行检测。回顾性统计分析送检的女性及男性泌尿生殖道感染患者的尿道/宫颈分泌物支原体鉴定及药物敏感情况。结果 送检的1080例标本中共检出支原体440例，总检出率为40.7%，其中解脲支原体（Uu）356例（80.9%），解脲支原体合并人型支原体（Uu +Mh）46例（10.4%），人型支原体（Mh）38例（8.6%）。药敏结果表明，强力霉素、交沙霉素、美满霉素敏感率较高，其次为克拉霉素、阿奇霉素。氧氟沙星、司帕沙星、罗红霉素的敏感性较低。结论 本院支原体感染以解脲支原体为主，强力霉素交沙霉素可作为目前治疗泌尿生殖道Uu和 Mh感染的首选药物，临床治疗前应尽可能进行支原体培养及药敏试验，合理规范用药。关键词泌尿生殖解脲支原体人型支原体药物敏感试验R828.2 文献标识码：B Infection of Mycoplasma in Urogenital System and the Study of Drug Resistance ZHANG Li-hong XU Ji-xun SHI Fang (Department of Laboratory, Huangshi Traditional Chinese Medicine Hospital, Huangshi 435000, China) [Abstract]Objective To investigate Urogenital Mycoplasma infection and drug sensitivity in Huangshi Traditional Chinese Medicine Hospital from January 2009 to June 2010. Methods Zhuhai?Encode?Medical?Engineering?Co.,?Ltd provided mycoplasma detection kit to detect .440 cases were positive mycoplasma among 1080 cases, accounting for 40.7% of the total. Among 440 clinical isolates, 356 cases were ureaplasma urealyticunm (Uu) positive (80.9%), 46 cases were Uu and mycoplasma hominis (Mh) complicated infection positive (10.4%), 38 cases were Mh positive (8.6%). The result of drug sensitivity test showed that the sensitive antibiotics were doxycyline josamycin and minocyline, the next was clarithromycin and Azithromycin. Increasing resistance trend for ofloxacin, spafloxacin and roxthromycin. Conclusions Urogenttal Mycoplasma infection shows principally as Uu, doxycyline and josamycin maybe selected as the fist drug to treat mycopalsma infection. [Key words] Urogenital System; Ureaplasma urealyticunm; Mycoplasma hominis; Drug sensitivity test 支原体是一类缺乏细胞壁的原核细胞型微生物，大小一般在0.30.5μm，呈高度多形性。它不同于细菌也不同于病毒，是介于细菌与病毒之间且能在人工培养基上生长的最小病原微生物。从人体分离的16种支原体中，解脲支原体（Ureaplasma urealyticum）和人性支原体（Mycoplasmhominis，Mh）是生殖系统常见的病原体，可引起非淋菌性尿道炎、尿路结石、前列腺炎等多种疾病，也是引起女性盆腔炎的重要病原菌，病与男性不育及女性