AmbulatoryDiabetesMellitus分析.pptVIP

Ambulatory:Diabetes Mellitus April 9, 2007 Subtypes Insulin dependent (Type 1 /IDDM) Abrupt onset, 30 yrs Autoimmune insulin deficiency due to islet cell destruction Prone to ketoacidosis Non-insulin dependent (Type 2/NIDDM) Gradual onset, 30 yrs Obesity Insulin resistance Impaired insulin secretion (beta cell dysfunction) Type I DM Insulin deficiency secondary to β-cell destruction usually by autoimmune process Insulin and C-peptide levels low May have islet cell autoantibodies, Autoantibodies to insulin, or antibodies to glutamic acid decarboxylase or tyrosine phosphatases. 20% risk of