Insearchofacancergene分析.pptVIP

In search of a cancer gene In search of a cancer gene You will search for a gene by Pedigree Analysis Gel electrophoresis Sequencing Data Pedigree of “Valerie’s” family (3-130) Label Photo with typed figure legend and data interpretation ID “children” that carry mutation from DNA sequences Hereditary versus Somatic Mutations Germline Somatic Some well known germline mutations that result in cancer are: Li-Fraumeni Syndrome What does the pedigree of a Li-Fraumeni patient look like? A sarcoma patient is included At least two immediate relative with other cancers before the age 45 As well