Drug Metabolism 药物代谢.pptxVIP

Chapter 2 Drug Metabolism;Drug metabolism;Definition of Metabolism;Pathways of Metabolism;Oral bioavailability;Clinical Significance;Contents;Metabolism Pre-exercise;Review Organic chemistryFunctional groups;Pathways of Metabolism;Phase I Reactions;Phase I Reactions;1, Oxidation and  Hydroxylation;CYP3A4;Aliphatic hydroxylationalkyl;Aliphatic hydroxylation alkyl;alkyl;Benzylic hydroxylation;Benzylic hydroxylation; Allylic hydroxylation;Machanism of action;Heteroatom, N ;N-Dealkylation;?-hydrogen oxidation ;N-Dealkylation;O- and S-Dealkylation;O- and S-Dealkylatio