hif1和2转录因子.pdfVIP

Mol. Cells 29, 435-442, May 31, 2010 DOI/10.1007/s10059-010-0067-2 Molecules and Minireview Cells ©2010 KSMCB HIF-1 and HIF-2 Transcription Factors - Similar but Not Identical Agnieszka Loboda*, Alicja Jozkowicz, and Jozef Dulak* Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodi- oxygen-regulated α-subunit and the constitutively expressed meric transcription factors mediating the cellular response 91-94 kDa β-subunit (also known as the aryl hydrocarbon re- to hypoxia. Recent data indicate that not only ubiquitous ceptor nuclear translocator, ARNT). There are three isoforms of HIF-1α, but also more cell-specific HIF-2α, is an important the HIF-α subunit (HIF-1α, HIF-2α, and HIF-3α), and three regulator of the hypoxia response. Although both α sub- paralogues of HIF-1β (Arnt1, Arnt2 and Arnt3) (reviewed in: units are highly conservative at protein level, share similar Zagorska and Dulak, 2004). HIF-1α and HIF-2α are particularly domain structure, heterodimerize with HIF-1β, and bind to critical for the hypoxia response, and are able to form complex the same DNA sequence called hypoxia responsive ele- with HIF-1β. The role of HIF-3α is less well understood, but it ment (HRE), their effect on the