在药动学、药效学方面的特点及成人有所不同,.PDF

老年癫痫患者卡马西平、丙戊酸血药浓度监测结果分析 金友国，王焰兵，洪庆(温岭市第一人民医院，浙江 温岭 317500) 摘要：目的 探讨老年癫痫患者卡马西平、丙戊酸血药浓度监测情况。方法 对262 例常规服用卡马西平、丙戊酸钠老 年癫痫患者进行血药浓度监测。结果 卡马西平组有 13.75%低于有效血药浓度，5%高于有效血药浓度，81.25%达到有 效血药浓度。而丙戊酸组有 51.96%低于有效血药浓度，3.92%高于有效血药浓度，44.12%达到有效血药浓度。丙戊酸组 达到有效血药浓度的比率明显低于卡马西平组(P ＜0.01) ，而两组高于有效血药浓度的比率基本相似(P ＞0.05) 。结论 患 者在给予卡马西平或丙戊酸钠初次使用剂量后达到有效浓度的比率存在一定差异。临床医师在应用抗癫痫药物时应实施 个体化给药。 关键词：卡马西平；丙戊酸；血药浓度；老年癫痫患者 中图分类号：R969.11 文献标志码：B 文章编号：1007-7693(2010)07-0654-03 作者简介：金友国，男，主管药师 Tel:E-mail: wlsjnk@ ·654 · Chin JMAP, 2010 July, Vol.27 No.7 中国现代应用药学2010 年 7 月第 27 卷第 7 期 Analysis of Serum Concentration of Carbamazepine, Valproic Acid in Elderly with Epilepsy JIN Youguo, WANG Yanbing, HONG Qing(The First People’s Hospital of Wenling, Wenling 317500, China) ABSTRACT: OBJECTIVE To investigate serum concentration of carbamazepine, valproic acid in elderly patients with epilepsy. METHODS Monitored the serum concentration of carbamazepine and valproic acid in 262 patients with epilepsy. RESULTS About 13.75% patients’ blood concentration lower than the effective blood concentration, 5% higher than the effective blood concentration and 81.25% reached the effective blood concentration in carbamazepine group. About 51.96% patients’ blood concentration lower than the effective blood concentration, 3.92% higher than the effective blood concentration and 44.12% reached the effective blood concentration in valproic acid group. The results showed that the number of patients reached the effective blood concentration in valproic acid group significantly lower than that of carbamazepine group (P0.01), but the number higher than the effective blood concentration in two groups was similar (P0.05). CONCLUSION The two groups’ patients, who were given the initial dose of carbamazepine or