全英文食品生物技术课程论文.docVIP

研究生课程论文 题 目: Bacterial Resistance to Antimicrobial Peptides 姓 名: 课 程: 专 业: 学 号: 指导教师: 职称: 2016年 1 月 15 日 Abstract:Resistant bacterial infections are a major health problem in many parts of the world. The major commercial antibiotic classes often fail to combat common bacteria.Antimicrobial peptides (AMPs) are able to control bacterial infections by interfering with microbial metabolism and physiological processes in several ways.However, successful pathogens have developed mechanisms to resist AMPs.To gain a better understanding of the resistance process various technologies have been applied.we review progress on the use of in vivo infection models in AMP research and discuss the AMP resistance mechanisms that have been established by in vivo studies to contribute to microbial infection.we discuss multiple strategies by which bacteria could develop enhanced antimicrobial peptide resistance, focusing on sub-cellular regions from the surface to deep inside, evaluating bacterial membranes, cell walls and cytoplasmic metabolism. Key word:Antimicrobial peptides; resistance; Membrane; cell wall 1 Introduction In recent years, antibiotic resistance has increasingly become an uncontrollable health problem. Bacterial infections caused by resistant strains can be found in hospitals around the world, being extremely common in immune compromised patients [1]. Antibiotics are able to control bacterial infections, interfering with microbial metabolism and physiological processes, such as DNA replication and cell wall biosynthesis. Although multiple compounds are often used, cases of resistance to the majority of antibiotic classes used in hospitals have been reported. The last report from the American Centers for Disease Control estimated that over two million illness