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• 784 • ( )
JTCMP , April 2012, Vol . 27, No. 4
Multi-phase and multivariate statistical process control for alcohol precipitation of water
extract of Lonicerae Japonicae
XU Bing, SHI Xin-yuan, QIAO Yan-jiang, DU Min, SUI Cheng-lin, LIU Qian
( School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China )
Abstract: Objective: To establish the multi-phase and multivariate statistical process control strategy for alcohol
precipitation of water extract of Lonicerae Japonicae . Methods: Based on the concept of PAT, NIR technology was applied to
monitor the alcohol precipitation process in real time. Then the process was divided into several phases by sequential clustering
2
analysis using the process NIR spectra. The MSPC models as well as the Hotelling T and SPE control limits were built for the
whole process and each phases.The effects of the whole process MSPC model and phase based MPSC model were compared.
Results: Alcohol
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