氧化应激与自噬在动脉粥样硬化中的作用研究新进展_郝阳.pdfVIP

404 ISSN 1007-3949 Chin J Arterioscler ，Vol 25 ，No 4 ，20 17 ·文献综述 · ［文章编号］ 1007-3949 (2017)25-04-0404-07 氧化应激和自噬在动脉粥样硬化中的作用研究新进展 1 2 2 郝阳 ，郭晓辰 ，张军平 (1．天津中医药大学研究生院，2．天津中医药大学第一附属医院心内科，天津市300193) ［关键词］氧化应激; 自噬; 动脉粥样硬化 ［摘 要］动脉粥样硬化是一种累及全身大、中动脉的多因素、多步骤失调性病变，是各种心脑血管疾病的病理基 础。动脉粥样硬化的发病机制目前仍不完全清楚。近年来国内外越来越多的证据表明，氧化应激和自噬是动脉粥 样硬化形成和发展的关键因素。氧化应激通过直接氧化损伤和间接信号介导损伤促进了动脉粥样硬化的发生发 展;自噬具有抗动脉粥样硬化和促动脉粥样硬化的双重作用;二者又有错综复杂的交联关系。本文分别从氧化应 激在动脉粥样硬化中的作用、自噬在动脉粥样硬化中的作用、氧化应激和自噬在动脉粥样硬化中的交联作用三方 面展开论述，为疾病的认识和治疗提供新思路。 ［中图分类号］Ｒ363 ［文献标识码］ A The new progress of the role of oxidative stress and autophagy in atherosclerosis HAO Yang1 ，GUO Xiao-Chen2 ，ZHANG Jun-Ping2 (1． Graduate School ，Tianj in University of Traditional Chinese Medicine ，Tianj in 300193 ，China ;2．Dep artment of Cardiolo- gy ，the First Aff iliated Hosp ital ，Tianj in University of Traditional Chinese Medicine ，Tianj in 300193 ，China) ［KEY WOＲDS］ Oxidative stress ; Autophagy ; Atherosclerosis ［ABSTＲACT］ Atherosclerosis ，the pathological basis of various kinds of cardiovascular diseases ，is a kind of disease of multifactorial and multistep disorder involving the whole-body large-and medium-sized arteries． The pathogenesis of ather- osclerosis is still not fully understood． There is growing evidence that oxidative stress and autophagy are two key factors in the formation and development of atherosclerosis in recent years at home and abroad． Oxidative stress accelerates the oc- currence and development of atherosclerosis through direct oxidative damage and indirect signal mediated injury ;Autophagy possesses double functions of resisting and promoting the atherosclerosis． Whil