什么是夫妻？什么是家？(国外英语资料).doc

什么是夫妻？什么是家？ Progress in pulmonary delivery of liposomes Bi Ru, Shao Wei * (School of pharmacy, Shandong University, Jinan 250012) Abstract: This paper introduces the characteristics and methods of liposome for pulmonary medicine, reviewed the related lipid carrier at home and abroad in recent years as antibiotics, antiasthmatic drugs, anticancer drugs, peptides and protein drugs and gene drugs, through the study of pulmonary delivery of local and systemic therapeutic effects, and to evaluate its safety. Keywords: liposomes; pulmonary delivery; drug delivery; safety Liposomes have a long history of pulmonary administration and have been used to treat respiratory distress syndrome at first. In 1979 McCullough and [1] found that beta cytarabine solution by intratracheal instillation after quickly cleared from the lung, and the mixed liposomes hardly to other tissues and distribution of suspension, and has remained in the bronchial space, so the early research focused on the treatment of pulmonary local disease. Along with the development of gene drugs, pharmaceutical excipients, new devices and new drug development, and liposome itself has the properties of high bioavailability, fewer adverse reactions, sustainable slow drug release, liposome as a carrier of local or systemic drugs for pulmonary drug delivery has been paid more and more attention, the relevant research progress is summarized as follows. 1. liposome lung administration characteristics Compared with other routes of administration, pulmonary delivery has the following characteristics: (1) it is easy to be administered, and is mainly administered by inhalation. The patient has a strong compliance. The absorption surface area is large, and the absorption site is rich in blood flow, and the drug exchange distance is short and the speed is fast. Lungs are composed of monolayer epithelial cells. The epithelial barrier is thinner and the membrane permeability is high, which can efficiently deliver macromolecula