cd59特异位点短肽封条对t细胞封闭作用(国外英语资料).docVIP

cd59特异位点短肽封条对t细胞封闭作用(国外英语资料) Cd59 special site short peptide seals are closed to t cells Source: / 【 abstract 】 objective to explore the effect and possible mechanism of short peptide seals containing cd59 specific sites. Methods a mouse model of hela tumor was established, and the blood separation serum was measured by c3 and c4. Mab and cd59 special site short-peptides were used to detect the proliferation of t cells after 48 h. As a result, the tumor mice complement c3 and c4 significantly lower (t = 30.970, 16.789, p 0.01). Cd59? Mab promoting effect on t cell proliferation and the short peptide containing cd59 specific loci seals can inhibit t cell proliferation, both have significant difference compared with normal controls the action of the (t = 5.428, 4.726, p 5.428). Conclusion cd59 is involved in t cell signal transduction and does not have to do with complement inhibition, and the short peptide seals containing cd59 specific sites are closed to t cells. [keywords] antigen, cd59; Short peptide seals; Tumor; T lymphocyte; Cell proliferation Cd59 is the height of the small molecule gpi anchoring protein glycosylation, widely distributed in hematopoietic cells, and the surface of hematopoietic cells and a variety of tissues and cells, its main function is to adjust the complement activation, with complement membrane attack complex (MAC) assembly c8 and (or) in the process of c9 combination to inhibit the activation of complement 1. In addition to the widely recognized regulatory complement, it also has the function of cell signaling. Studies have shown that the body of a tumor patient is in an immunocompromised state, and this imbalance is associated with the t cell signaling defect. T cells in tumor patient airframe, the expression of cd59 play a role in the process of cell signal transduction and affect t cell activity, has not yet been reported in the literature at home and abroad. Through the establishment of mouse tumor model, this paper studies a tumor