放射性咽喉炎是头颈部肿瘤放疗中常见的并发症，表现为咽干痛不适.docVIP

痰热清注射液治疗头颈部肿瘤急性放射性粘膜损伤的临床研究 [摘要】 目的：观察痰热清注射液治疗头颈部恶性肿瘤患者急性放射性口腔炎的作用。方法 头颈部性肿瘤患者50例，随机分为2组，治疗组25例，放疗第3周开始时用痰热清注射液治疗，对照组25例采用常规处理。结果：治疗组以I、Ⅱ级口咽粘膜损伤为主(76％)。对照组以III、Ⅳ级的损伤为主(60％)，两组比较有显著差异(P0．05)；治疗组口咽部疼痛以0-3分（轻度）为主，对照组以4-6分（中度）为主，治疗组及对照组患者放疗后口咽部疼痛呈轻度、中度、重度分别占72％、24％、4％及12％、64％、24％，两组比较有统计学差异(P0．05)结论：痰热清注射液对急性放射性口腔、咽喉炎有较好的治疗效果，具有减轻口腔、咽黏膜放射性损伤、抗炎镇痛和加速创面愈合的作用。 [关键词] 痰热清注射液；放射性；粘膜损伤；头颈部恶性肿瘤 【中图分类号】R739．63 【文献标识码】B Study of the therapy effect of Tanreqing zhusheye in Acute irradiation mucosal injury in patients with the head and neck cancer. Huang Xiong，Cai Chuan Shu.Department of Radiation Oncology，The First Affiliated Hospital of Fu Jian Medical University，Fu Zhou 350000，China. 【Abstract】Objective:To observe the therapy effect of Tanreqing zhusheye in acute irradiation oropharyngeal mucositis in patients with the head and neck cancer．Methods: Fifty patients with the head and neck cancer were randomized into treatment group and control group．Patients in the treatment group received concurrently intravenous infusion of Tanreqing zhusheye during irradiation course.Patients in the control group received daily regular oral nursing；oropharyngeal mucositis was evaluated according to the protocol proposed by RTOG. grade of acute irradiation oropharyngeal mucositis were observed.Results: Comparing with the grade of acute irradiation mucositis between the two groups,there was a significant difference(P0．05);respectively.Conclusion : Tanreqing zhusheye can therapy acute irradiation oropharyngeal mueositis of the head and neck cancer and decrease the incidence of grade III and IV mucositis． 【Key Words】Tanreqing zhusheye；irradiation；Mucosal injury; the head and neck cancer 放射性口腔、咽喉炎是头颈部肿瘤放疗中常见的并发症，表现为口腔、咽喉部干痛不适，影响进食，口腔、咽粘膜充血、水肿、糜烂和白膜形成，影响放疗的顺利进行，不仅降低了放疗的疗效，同时患者的生存质量明显下降。为探讨和寻找降低放射性粘膜炎、口腔反应的新方法，我科2008年11月到2010年6月采用痰热清注射液治疗头颈部肿瘤放疗所致放射性口腔、咽喉炎50例，疗效满意。现报告如下： 1．资料与方法 1．1 一般资料 头颈部肿瘤患者50例，均经病理确诊，均接受术后辅助放疗。随机分为两组。治疗组25例，其中口腔癌15例，喉癌5例，下咽癌5例，男性17例，女性8例，年龄33-63 岁，平均65.1岁；对照组25例，其中口腔癌13例，