20160807-化浊通络法对酒精性肝炎患者血清炎性因子干预作用与疗效评价.docVIP

化浊通络法对酒精性肝炎患者血清炎性因子的干预作用及疗效评价 【摘要】 目的：观察化浊通络法对酒精性肝炎（AH）患者血清炎性因子的干预作用及临床疗效。方法：116例AH患者随机分为观察组和对照组，在常规治疗基础上，对照组采用水飞蓟宾葡甲胺片进行治疗，观察组采用化浊通络法，比较两组血清肝功能指标、炎性因子，并评价临床疗效。结果：两组治疗前血清肝功能指标（ALT、AST、GGT）和炎性因子（CD40L、IL-1、IL-6及hs-CRP）比较，差异均无统计学意义（P0.05）；与对照组治疗后比较，采用化浊通络方的对照组患者血清肝功能指标ALT、AST、GGT均改善的更为明显（t=9.901、5.078、8.529，均P0.05）；对照组总有效率为67.2%，明显低于观察组的93.1%（χ2=21.125，P=0.001）；血清中炎性因子如CD40L、IL-1、IL-6及hs-CRP也显著降低（t=8.512、11.335、6.668、6.337，均P0.05）。结论：化浊通络方能明显改善AH患者的临床不适症状，保护AH患者肝功能，抑制炎性因子，减轻肝损伤，提高治疗效果，具有一定临床应用价值。 关键词：化浊通络；酒精性肝炎；炎性因子；疗效 The intervention effect of Hua-Zhuo-Tong-Luo on serum inflammatory factorsin patients with alcoholic hepatitis and evaluation of its curative effect [abstract] objective: To observe the intervention effect of Hua-Zhuo-Tong-Luo on serum inflammatory factorsin patients with alcoholic hepatitis and evaluate its curative effect. Methods: 116 patients with AH were randomly divided into observation group and control group, on the basis of conventional treatment, Silibin Meglumine Tablets were used in the control group, Hua-Zhuo-Tong-Luo was used in observation group. The serum liver function index, inflammatory factors were compared, the clinical efficacy were evaluated. Results: The serum liver function index (ALT, AST, GGT) and inflammatory factor (CD40L, IL-1, IL-6 and hs-CRP) were no statistically significant difference between control group and observation group before treatment (all P0.05). Compared with the control group after treatment, serum liver function index of ALT, AST, GGT in observation group were improved more significantly (t=9.901, 5.078, 8.529, P0.05); The control group total effective rate was 67.2%, significantly less than 93.1% of the observation group (χ2=21.125，P=0.001). Serum inflammatory factors such as CD40L, IL-1, IL-6 and hs-CRP also significantly lower in observation group(t=8.512, 11.335, 6.668, 11.335, P0.05). Conclusion: Hua-Zhuo-Tong-Luo can obviously improve the clinical symptoms in patients with AH, can protect liver func