头孢西丁钠制备.docVIP

摘 要头孢西丁钠是由链酶菌产生的甲氧头孢菌素C经半合成制得的一类新型抗生素，通过抑制细菌细胞壁的合成而杀灭细菌。头孢西丁钠作为第二代头孢菌素类抗生素，与第一代头孢菌素比较，其抗菌谱更广。本文介绍了以头孢噻吩酸为原料，甲氧基化产物不需结晶提纯而直接用于去乙酰化，缩短了生产周期和节省了原料。本方法制备简便，适于工业化生产。又通过对成盐剂和有机溶剂的筛选，对头孢西丁钠的结晶工艺进行优化，得到晶型好、质量高、成本低的头孢西丁钠产品，产率大于95%。本方法操作简便，成本低廉，适于工业化生产。关键词：头孢西丁钠；头孢菌素；药物合成；结晶 AbstractCefoxitin sodium is produced by streptomyces methoxyl cephalosporin C by the new class of antibiotics, semisynthetic made by inhibiting the synthesis of bacterial cell walls and kill bacteria.Cefoxitin sodium as the second generation of cephalosporin antibiotics, compared with the first generation cephalosporin, its wider antibacterial spectrum. Cefalotin acid as raw materials were introduced in this paper, the methoxyl group products without crystallization purification and directly used to acetylation, shorten the production cycle and save the raw material. The preparation method is simple, suitable for industrial production.And through the salt agent and organic solvent screening, to optimize the crystallization process of cefoxitin sodium and get good crystal shape, high quality, low cost of products, cefoxitin sodium production rate is more than 95%. This method is simple, low cost, suitable for industrial production.Key words: cefoxitin sodium; cephalosporins; drug synthesis; crystallization目 录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc323502242 摘 要 ...........Ⅰ HYPERLINK \l _Toc323502243 Abstract .Ⅱ HYPERLINK \l _Toc323502245 第1章 文献综述 1 HYPERLINK \l _Toc323502246 第1节 头孢西丁钠的研究背景 1 HYPERLINK \l _Toc323502247 第2节 抗生素类药物 2 HYPERLINK \l _Toc323502247 第3节 头孢西丁的特点 4 HYPERLINK \l _Toc323502247 第4节 头孢西丁钠的合成的方法 4 HYPERLINK \l _Toc323502248 第2章 实验部分 6 HYPERLINK \l _Toc323502249 第1节 实验仪器与试药 6 HYPERLINK \l _Toc323502247 第2节 头孢西丁钠的合成原理 6 HYPERLINK \l _Toc323502250 第3节 头孢西丁钠的合成与质量检测实验 7 HYPERLINK \l _Toc323502247 第3章 结果与讨论 9 HYPERLINK \l _Toc323502247 第1节 有机溶剂的选择对收率的影响 9第2节 质量及稳定性的考察............................................................................................ 9 HYPERLINK