催产素对能量平衡作用机制（.docVIP

催产素对能量平衡的作用机制( 朱永香1*，王 倩1, 王爽2 1．西安医学院基础医学部生理学教研室，西安 710021 2．西安医学院基础医学部病理生理学教研室，西安 710021 投稿日期2013-09-19 接受日期2013-12-18 ([基金项目] 国家自然科学基金资助课题(8110665)，陕西省教育厅科研基金资助课题（2013JK0761,2013JK0755）National Natural Science Foundation of China for Young Scientists(8110665), Scientific Research Fund of Shaanxi Provincial Department of Education（2013JK0761，2013JK0755） [作者简介] 朱永香，女，副教授， E-mail: yxzhu999@163.com * 通信作者（corresponding author）, Tel: 029 E-mail: yxzhu999@163.com 【摘要】肥胖症是一种高度复杂的代谢紊乱疾病，其机制牵涉到调控食物摄入和能量支出的中枢机制。虽然导致肥胖的基本发病机制尚不清楚，但是催产素（Oxytocin, OT）在体重的调控中无疑发挥了重要作用。以前的研究表明，中枢或外周给予OT产生厌食作用。但近来，有研究表明OT或其受体缺乏的啮齿类动物发展为迟发性肥胖，而总的食物摄入量却没有变化，这表明OT对能量代谢的调节具有重要的作用。本文对OT在能量平衡调控中的作用进行了详细论述，侧重于阐明OT在食欲调控、体温调节及能量代谢中的作用。 【关键词】肥胖；催产素；食欲调控；体温调节；能量代谢 【中图号】R338.2 【文献标识码】A Action of oxytocin on balance of energy and the related mechanism ZHU Yong-xiang1*, WANG Qian1, WANG Shuang2 1．Department of Physiology , Xian Medical College, Xian 710021, Shaanxi, China 2．Department of Pathophysiology , Xian Medical College, Xian 710021, Shaanxi, China Abstract: Obesity is a complex metabolic disorder involving central mechanisms controling food intake and energy expenditure. Though the mechanisms of obesity are not fully understood, oxytocin undoubtedly plays a role in regulating body weight. Previous studies have shown that central or peripheral oxytocin administration induces anorexia. However, recently some researches have shown that rodents lack of oxytocin or its receptor can develop late-onset obesity with no total food intake change, which indicates an important role of oxytocin in energy metabolism. In this paper we discussed the effects of oxytocin on energy balance in details, with a special focus on the role of oxytocin in appetite regulation, thermoregulation, and energy metabolism. Key words: obesity, oxytocin, appetite regulation, thermoregulation, energy metabolism. 肥胖症是一种复杂的代谢紊乱疾病，其机制牵涉到调控食物摄入和能量支出的中枢机制。肥胖症及其相关的代谢性疾病在全世界范围内以惊人的速度流行，有效地预防和控制肥胖已成为刻不容缓的任务。虽然导致肥胖的基