pdf 1992kb - 药学学报.doc

星型聚乳酸对海藻酸钠的疏水改性及释药性能研究 马福文1, 靳 勇2*, 张文芳3, 周绍兵4, 倪才华1* (1. 江南大学化学与材料工程学院, 江苏 无锡 214122; 2. 苏州大学第二附属医院, 江苏 苏州 215123; 3. 无锡世林微纳医疗器械有限公司, 江苏 无锡 214000; 4. 西南交通大学材料科学与工程学院, 四川 成都 610031) 摘要: 本文以多羟基笼型倍半硅氧烷 (POSS-OH) 为核, 用辛酸亚锡催化丙交酯开环聚合, 获得了无机/聚合物杂化星型聚乳酸 (POSS-PLA), 用其对海藻酸钠疏水改性合成了药物载体, 采用布洛芬作为药物模型进行药物释放的研究。结果表明, 改性海藻酸钠微球的包封率有一定提高, 缓释效果明显。随着POSS-PLA在微球中含量增加, 释放速率减缓, 释放机制从一级释放逐渐向零级释放过渡。 药物载体; 藻酸盐; 星型聚乳酸A 文章编号: 0513-4870 (2010) 11-1447-05 Drug release properties of sodium alginate hydrophobically modified by star polylactic acid MA Fu-wen1, JIN Yong2*, ZHANG Wen-fang3, ZHOU Shao-bing4, NI Cai-hua1* (1. School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China; 2. Second Affiliated Hospital of Suzhou University, Suzhou 215123, China; 3. Shilin Weina Medical Devices Wuxi Co., Ltd., Wuxi 214000, China; 4. Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China) Abstract: Inorganic/polymer hybrid star polylactic acid (POSS-PLA) was obtained through ring-opening polymerization of lactide by using polyhydroxyl cage silsesquioxane (POSS-OH) as the core and tin (II) octoate as the catalyst. The star polylactic acid (POSS-PLA) was used to modify sodium alginate hydrophobically and a drug carrier was obtained. The drug release behavior was investigated by using ibuprofen as the model drug. The results showed that the drug loading rate could be improved and the release rate was postponed with an increase of POSS-PLA content in the carries. The release mechanism gradually changed from the first-order to the zero-order pattern after the modification. Key words: drug carrier; alginate; star polylactic acid (海藻酸钠 (sodium alginate或 Alg) 是由β-D-甘露糖醛酸 (M) 和α-L-古洛糖醛酸 (G) 两种单体组成的嵌段线性聚合物, 可与二价阳离子钙、锌等在温和条件下形成多种性能要求的凝胶, 海藻酸钠且具有良好的生物相容性及可生物降解, 被广泛地用作药物、蛋白质及细胞载体材料[1, 2]。聚乳酸是一种具有优良的生物相容性和可生物降解的聚合物, 聚乳酸在体内代谢最终产物是二氧化碳和水