抗NMDAR抗体脑炎研究进展.pdfVIP

·84· ·综述与讲座· 抗NMDAR抗体脑炎研究进展 周 晶 秦新月△ 重庆医科大学附属第一医院 重庆400016 【摘要】抗N一甲基一M一天冬氨酸受体(N—methyl—D-aspartate 叶脑炎(1imbic 期的上感症状发展到精神异常、意识障碍、异常运动和自主神经功能紊乱、癫痢发作、中枢性通气功能障碍为常见表现。脑脊 液常为炎性改变。MRI在大脑皮质或小脑叮表现短暂异常或颞叶内侧高信号影改变。脑电图多为非特异性改变。血及脑脊 液抗NMDA受体抗体阳性可确诊。包括肿瘤切除和免疫治疗、重症监护和物理康复在内的联合治疗为最佳治疗方案。本文 就抗NMDA受体脑炎的研究进展做一综述。 【关键词】边缘叶脑炎；抗N一甲基一M一天冬氨酸受体抗体；N一甲基一M一天冬氨酸(NMDA)；畸胎瘤 【中图分类号】R749．1+1【文献标识码】A 【文章编号11673-5110(2011)17—0084—03 Researchontheadvancesof Zhou anti—N-methyl—D-aspartate Jing。Qin Fi坶f Medical 400016，China Xinyue．The ofChongqing AffiliatedHospital University，Chongqing isa describeddisorderofaclassof [Abstract]Anti-N—methyl—D-aspartatereceptor(NMDAR)encephalitisrecently para— limbic andmechanismisnotclearSOfar．Theincidenceofanti—NMDAR neoplasticencephalitis(IE)。which’Setiology enceph— alitisislowandthedisorder affects womenwithteratomasofthe who a illness ovary multistage predominantlyyoung develop frominfluenza tO disorders，consciousness，abnormalmovements，autonomic progresses symptomspsychiatric dysfunction，epi- andcentralventilation showa dysfunction．Thecerebrospinal hasinflammatory may lepsy fluid(CSF)usuallychanges．MRI andabnormal inthecerebralcortex，eerebellarandmedial temporary hyperintensitysignal temporal abnormalinmost canbe anti-NMDA inserumandce— detecting antibodies grams(EEG)ar