聚乙二醇丙烯酸酯的合成与表征 - 现代生物医学进展.pdf

Pro ress in Modern Biomedicine 2006 Vol. 6 No. 5 41 聚乙二醇丙烯酸酯的合成与表征 刘亚兰 雷忠利 赵俊超 ( 陕西 西安710062) : 以聚乙二醇- 400( PEG400) 与丙烯酸直接缩合反应, 在不加有 带水剂的条件下合成了丙烯酸聚乙二醇酯( PEGA) 通过正交实验确定酯化反应的最佳条件: 丙烯酸/ PEG400 的摩尔比为2. 0 : 1. 0 , 反应温度是110 , 阻聚剂对苯二酚为0 . 4% ( 以醇 酸总质量计) , 反应时间为6 小时, 催化剂对甲苯磺酸为0. 8% ( 以醇酸总质量计) , 产率为76. 7% 产品结构经IR 和 1HNMR 表 征, 证明是所需的产物 : 聚乙二醇丙烯酸酯; 正交实验; 合成; 表征 : O621. 25 : A Synthesis and Characterization of Polyethylene Glycol Acrylate LI U Ya- lan, LEI Zhong- li, ZHAO Jun- chao College of Chemistry and Materials Science, Shaan iN ormal University, Xi an 7 10062, China ABSTRACT: Polye hylene glycol acryla e ( PEGA) w as syn hesized by condensa ion of PEG( 400) and acrylic acid wi hou w a er- car rying reagen . T he op imal condi ion of es erif ica ion was s udied by he or hogonal design ha he molar ra e of acrylic acid o PEG was 2. 0 : 1. 0 , he reac ion empera ure w as 110 , he reac ion ime is 6h, he amoun of hydroquinone and p- me hy benzene sulfonic acid w as 0 . 4% and 0 . 8% , respec ively ( according o he mass of PEG and acrylic acid) . The s ruc ure of he PEGA w as charac erized by FTIR, and 1HNMR. . The es er yield reached 81% according o 1HNMR. Key words: Polye hylene glycol acryla e; Or hogonal design ; Syn hesis; Charac eriza ion , ( ) , [ 1~ 6] PEGA PEGA , , , , , 1 ; , 1. 1 : , [ 7] ( PEG - 400) , , ; SiO2 PEGA , ,