热重法研究绿原酸的热稳定性、分解动力学及贮存期.PDFVIP

- 348 - Drug Evaluation Research 第 34 卷 第 5 期 2011 年 10 月 热重法研究绿原酸的热稳定性、分解动力学及贮存期 * 郭满满，肖卓炳 ，于华忠，彭密军 吉首大学 林产化工工程湖南省重点实验室，湖南 张家界 427000 摘 要：目的 研究受热条件下绿原酸的热稳定性、分解动力学和贮存期。方法 利用 TG-DTG 技术测得绿原酸在氮气气 氛中不同升温速率（β）下的热分解曲线，协同使用Achar 法、Coats-Redfern 法、Kissinger 法和 Ozawa 法等 4 种方法进行动 力学处理，根据热分解的表观活化能（Eα）和指前因子（A ）计算推断绿原酸的贮存期。结果 随着升温速率的提高，绿原 酸的热分解温度逐渐升高；绿原酸三步热分解的机制依次是三维扩散、二维扩散和化学反应控制，对应的函数名称是 Zhuralev-Lesokin-Tempelman 方程、Janer 方程和反应级数方程；根据第一步热分解的 Eα和A 推断，在室温（25 ℃）下，绿 原酸的贮存期为 1.5～2 年。结论 4 种热分解动力学方法相互验证，获得了绿原酸的热分解动力学方程，由动力学参数求得 绿原酸的贮存期，可以为目前大量含绿原酸药品的质量监控提供依据。 关键词：绿原酸；热分析；非等温法；热分解动力学；贮存期 中图分类号：R927.2 文献标志码：A 文章编号：1674 - 6376 (2011) 05 - 0348 - 05 Study on thermal stability, decomposition kinetics, and shelflife of chlorogenic acid by thermogravimetry method GUO Man-man, XIAO Zhuo-bing, YU Hua-zhong, PENG Mi-jun Key Laboratory for Forest Products and Chemical Industry Engineering, Jishou University, Zhangjiajie 427000, China Abstract: Objective To study the thermal stability, decomposition kinetics, and shelflife of chlorogenic acid under the heat condition. Methods Thermal decomposing curves of chlorogenic acid in different heating speeds were obtained in the nitrogen atmosphere by TG-DTG techniques. Four thermal analysis kinetic methods (Achar, Coats-Redfern, Kissinger, and Ozawa) were used to speculate the probable mechanism of thermal decomposing reaction and the kinetic parameters. The shelflife of chlorogenic acid at room temperature (25 ℃) was calculated by the kinetic parameters of the first stage. Results With the improvement of the heating rate, thermal decomposing tempreture of chlorogenic acid rose. The most probable kinetic mechanisms of the three-stage thermal decomposition were three-dimensional diffusion, two-dimensional diffusion, and chemic