生物衍生骨复合成骨诱导骨髓间充质干细胞构建组织工程化骨修复兔桡骨-骨膜缺损的血管化进程.pdfVIP

中国组织工程研究与临床康复第12 者多27 JIIJ 2∞8 -07 - 01 出版 @吏在安基础实验 Journal ofClinical Rehabilitative 1íssue Engineering Research July 1, 2α)8号01.12， No.27 生物衍生骨复合成膏诱导骨黯间充质干细胞构建组织工程化膏修复 兔挠骨一青摸缺摄的血管化进程会 浩 朱肖奇，马雪峰，贺用花，郭 Vascularization of 刽掘出 engineered bone ωnstructed by bio-derived bone co-cultured with induced bone marrow mesenchymal s位mceUs部 repair segmental defe.;黯 of rabbit radius-periosteum Zhu Xiao-qi, Ma Xue-feng , He Yong品， GuoHao Abs位act d Deparu田It BACKGROUND: It is a key fc冒险survival of a transplan时boneω回scularize. Ortho归edics， OBJECτIVE: To 如dy the vascularization of r，句airing segrnental defi邸S ofra协it radius-periosteum by tiss鸥在ngineering bone Sht贸IZhen Ba值且 H困pi国I Af6liated 如 αmstructed by the 排αlture of bilHlerived bone with indu仅对bωemarro曹 mesenchymal 悔恨cells (BMSCs). S∞由ern Medical DESIGN , TIME AND SETTING: Randαnization design animalαmtrolled tria1s wen: performed at 出e I必oratory of l..ife Universíty, She田ben Science College of Nanhua Uni专ersity from January 2007 毫oJan回ry2∞8. 518101 , G旧ngdong MATERIALS: Twenty-five h ea1thy adult New Z臼land rabbits wen: ωedinth总部dy to establish a 15-mm length of 阮OVi国嚣.C副na radius-严riosteum defc回sonb锐h sides of radial bone. zhu 觅踏哼食， METHODS: Bio-derived bone scaffold was prepared wit握在 serial of physícal and chc班úcal pr()(黯ses， including degJ军:asing. D四1腥 Associa恒 chief pbysician. 缸proteínizati∞， partial 必保lcific却onand 企eeze drying. Bio也rived bone scaffold was thenω-cultw可d wíth iuduced BMSCs 牵O De严Z幢幢嚣 d C∞struαtissue engineering bones. w挝ch were ímplanted ín旬出e segrnen组1 bonedefc仅在S of 20 rabbits in right radius. taken as d勤E orth吨aedics， experimental group; Bi萨derived bone sc